We report a regioselective entry to 3-bromo- and 4-bromo-5-hydroxy-5H-furan-2-ones by photooxidation of 3-bromofuran with a singlet oxygen in the presence of a suitable base. By this procedure, a variety of 3-substituted ç-hydroxybutenolides have become for the first time easily accessible. Strategies employing these highly functionalized building blocks for the preparation of focused libraries of natural-like molecules are also discussed.

Regioselective Entry to Bromo-γ -hydroxybutenolides: Useful Building Blocks for Assemblying Natural Product-Like Libraries.

BRUNO, Ines;RICCIO, Raffaele;
2006-01-01

Abstract

We report a regioselective entry to 3-bromo- and 4-bromo-5-hydroxy-5H-furan-2-ones by photooxidation of 3-bromofuran with a singlet oxygen in the presence of a suitable base. By this procedure, a variety of 3-substituted ç-hydroxybutenolides have become for the first time easily accessible. Strategies employing these highly functionalized building blocks for the preparation of focused libraries of natural-like molecules are also discussed.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/1655382
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