Amides easily obtained from enantiopure (R)- and (S)-NOBIN and L-proline have been shown to promote the enantioselective direct aldol reaction under low catalytic loadings (5 mol%), in apolar hexane as the solvent and using only a slightly higher molar excess of the acetone with respect to the aldehyde. Aldol products are isolated in good to high yields and up to 77% ee at room temperature.
NOBIN-prolinamides organocatalyzed enantioselective direct aldol reaction: remarkable activity in apolar medium
RUSSO, ALESSIO;LATTANZI, Alessandra
2007-01-01
Abstract
Amides easily obtained from enantiopure (R)- and (S)-NOBIN and L-proline have been shown to promote the enantioselective direct aldol reaction under low catalytic loadings (5 mol%), in apolar hexane as the solvent and using only a slightly higher molar excess of the acetone with respect to the aldehyde. Aldol products are isolated in good to high yields and up to 77% ee at room temperature.File in questo prodotto:
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