Supercritical antisolvent (SAS) micronization has been used to obtain nanoparticles and micro-particles of several kinds of materials. Sometimes hollow expanded micro-particles have also been obtained. This work is focused on the analysis of this last morphology. We organized literature data and our previous experiments and we added new experiments on previously tested compounds and on compounds never tested before. As a result, expanded micro-particles using several compounds belonging to different categories and precipitated from different solvents in laboratory and pilot scale plants were obtained with diameters between about 10 and 180 m. They also showed different sub-structures: uniform or nanostructured surface or constituted by microcrystals. Also expanded micro-particles of coprecipitates were obtained. To explain all the available experimental evidences, we propose a mechanism of hollow expanded micro-particles formation, based on thermodynamic and mass transfer interactions.

Expanded micro-particles by supercritical antisolvent precipitation: Interpretation of results

REVERCHON, Ernesto
;
DE MARCO, Iolanda;ADAMI, RENATA;CAPUTO, GIUSEPPE
2008-01-01

Abstract

Supercritical antisolvent (SAS) micronization has been used to obtain nanoparticles and micro-particles of several kinds of materials. Sometimes hollow expanded micro-particles have also been obtained. This work is focused on the analysis of this last morphology. We organized literature data and our previous experiments and we added new experiments on previously tested compounds and on compounds never tested before. As a result, expanded micro-particles using several compounds belonging to different categories and precipitated from different solvents in laboratory and pilot scale plants were obtained with diameters between about 10 and 180 m. They also showed different sub-structures: uniform or nanostructured surface or constituted by microcrystals. Also expanded micro-particles of coprecipitates were obtained. To explain all the available experimental evidences, we propose a mechanism of hollow expanded micro-particles formation, based on thermodynamic and mass transfer interactions.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/1862092
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 64
  • ???jsp.display-item.citation.isi??? 56
social impact