The desymmetrization of N-acylaziridines with Me3SiSPh, catalyzed by commercially available (R) and (S)-VAPOL hydrogen phosphate, produced beta-(N-acylamino)phenylthioethers in a highly enantioselective and efficient manner (78-99% ee). The selection of the suitable aziridine/nucleophile/catalyst molar ratio is crucial to obtain high ee’s.

Highly enantioselective synthesis of beta-amidophenylthioethers by organocatalytic desymmetrization of meso-aziridines

DELLA SALA, Giorgio;LATTANZI, Alessandra
2009-01-01

Abstract

The desymmetrization of N-acylaziridines with Me3SiSPh, catalyzed by commercially available (R) and (S)-VAPOL hydrogen phosphate, produced beta-(N-acylamino)phenylthioethers in a highly enantioselective and efficient manner (78-99% ee). The selection of the suitable aziridine/nucleophile/catalyst molar ratio is crucial to obtain high ee’s.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/2279863
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