The first example of meso-aziridine desymmetrization with selenium nucleophiles is reported. The reaction, promoted by VAPOL-hydrogen phosphate using (phenylseleno) trimethylsilane as the nucleophile, proves to be very general and highly enantioselective (84–99% ee).
A general phosphoric acid-catalyzed desymmetrization of meso-aziridines with silylated selenium nucleophiles
LATTANZI, Alessandra;DELLA SALA, Giorgio
2011-01-01
Abstract
The first example of meso-aziridine desymmetrization with selenium nucleophiles is reported. The reaction, promoted by VAPOL-hydrogen phosphate using (phenylseleno) trimethylsilane as the nucleophile, proves to be very general and highly enantioselective (84–99% ee).File in questo prodotto:
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