Estimated glomerular filtration rate (eGFR) was used for analysis of kidney disease prevalence in the United States. The study investigated on prevalence, associated disorders, and kidney disease awareness in an Italian population sample. Data were collected on serum creatinine, other laboratory indices, blood pressure, and medical history in the Gubbio Population Study (n¼4574, both sexes, ages 18–95 years). Analyses were carried out on eGFR (equation of Modification Diet in Renal Disease study), disorders potentially secondary to kidney dysfunction (hypertension, high serum uric acid, high serum phosphorus/low serum calcium, high serum potassium, cardiovascular disease, anemia), and kidney disease awareness. The prevalence of eGFRo60 ml/min1.73m2 increased with age in both sexes (from o1% for ages 18–24 years to 430% for ages X75 years, Po0.001). In the group with eGFR o60 ml/ min1.73m2, number of disorders secondary to kidney dysfunction was X2 in the majority of persons, was higher than in persons with eGFR X60 ml/min1.73m2 (Po0.001), and was inversely related to eGFR (Po0.001). The prevalence of reported kidney disease was 3.3% in the group with eGFR o60 ml/min1.73m2 and directly related to serum creatinine and number of disorders secondary to kidney dysfunction (Po0.001). Low kidney function is frequent in the older population and is associated with disorders typical of kidney disease. Persons with low kidney function are rarely aware of kidney disease unless of very high serum creatinine or presence of many disorders typical of kidney disease.
Low glomerular filtration in the population: prevalence, associated disorders, and awareness.
CIRILLO, Massimo;
2006-01-01
Abstract
Estimated glomerular filtration rate (eGFR) was used for analysis of kidney disease prevalence in the United States. The study investigated on prevalence, associated disorders, and kidney disease awareness in an Italian population sample. Data were collected on serum creatinine, other laboratory indices, blood pressure, and medical history in the Gubbio Population Study (n¼4574, both sexes, ages 18–95 years). Analyses were carried out on eGFR (equation of Modification Diet in Renal Disease study), disorders potentially secondary to kidney dysfunction (hypertension, high serum uric acid, high serum phosphorus/low serum calcium, high serum potassium, cardiovascular disease, anemia), and kidney disease awareness. The prevalence of eGFRo60 ml/min1.73m2 increased with age in both sexes (from o1% for ages 18–24 years to 430% for ages X75 years, Po0.001). In the group with eGFR o60 ml/ min1.73m2, number of disorders secondary to kidney dysfunction was X2 in the majority of persons, was higher than in persons with eGFR X60 ml/min1.73m2 (Po0.001), and was inversely related to eGFR (Po0.001). The prevalence of reported kidney disease was 3.3% in the group with eGFR o60 ml/min1.73m2 and directly related to serum creatinine and number of disorders secondary to kidney dysfunction (Po0.001). Low kidney function is frequent in the older population and is associated with disorders typical of kidney disease. Persons with low kidney function are rarely aware of kidney disease unless of very high serum creatinine or presence of many disorders typical of kidney disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
