Objective: To determine whether pain is more frequent among people with Parkinson disease (PD) than among age-matched controls. Design : Case-control study Patients and Methods : Logistic regression models tak-ing into account type of pain, time between pain and PD onset, and possible confounders were used to compare 402 PD patients with 317 age-matched healthy control subjects. Results: The overall frequency of pain was signifi-cantly greater in PD patients than in controls (281 [69.9%] vs 199 [62.8%]; P = .04), mainly because the healthy con-trol group lacked dystonic pain. Conversely, the frequency of nondystonic pain was similar among PD pa-tients and controls (267 [66.4%] vs 199 [62.8%]; P = .28). Nevertheless, we observed a significant association be-tween PD and nondystonic pain, beginning after the on-set of parkinsonian symptoms (odds ratio, 2.1; 95% con-fidence interval, 1.4-2.9). Cramping and central neuropathic pain were more frequent among PD pa-tients than controls. About one-quarter of patients who experienced pain reported pain onset before starting antiparkinsonian therapy. Conclusion : These data support the hypothesis that pain begins at clinical onset of PD or thereafter as a nonmo-tor feature of PD.
Pain as a nonmotor symptom of Parkinson disease: evidence from a case-control study.
BARONE, Paolo;
2008-01-01
Abstract
Objective: To determine whether pain is more frequent among people with Parkinson disease (PD) than among age-matched controls. Design : Case-control study Patients and Methods : Logistic regression models tak-ing into account type of pain, time between pain and PD onset, and possible confounders were used to compare 402 PD patients with 317 age-matched healthy control subjects. Results: The overall frequency of pain was signifi-cantly greater in PD patients than in controls (281 [69.9%] vs 199 [62.8%]; P = .04), mainly because the healthy con-trol group lacked dystonic pain. Conversely, the frequency of nondystonic pain was similar among PD pa-tients and controls (267 [66.4%] vs 199 [62.8%]; P = .28). Nevertheless, we observed a significant association be-tween PD and nondystonic pain, beginning after the on-set of parkinsonian symptoms (odds ratio, 2.1; 95% con-fidence interval, 1.4-2.9). Cramping and central neuropathic pain were more frequent among PD pa-tients than controls. About one-quarter of patients who experienced pain reported pain onset before starting antiparkinsonian therapy. Conclusion : These data support the hypothesis that pain begins at clinical onset of PD or thereafter as a nonmo-tor feature of PD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
