Four pentacyclic guanidine derivs. [crambescidin 800 (I), crambescidin 816 (II), isocrambescidin 800 (III), and crambidine (IV), related to ptilomycalin A] have been isolated from the Mediterranean sponge C. crambe. III and IV are new derivs., the structures of which have been detd. on the basis of their spectral properties. The abs. configuration of II at the stereogenic center C-43 has been detd. by applying Mosher's method. Pharmacol. and biol. activities of the Crambe crambe alkaloids are reported. In particular, II was found to have a potent Ca2+ antagonist effect and to inhibit the acetylcholine-induced contraction of guinea pig ileum at very low concns.

Polycyclic guanidine alkaloids from the marine sponge Crambe crambe and calcium channel blocker activity of crambescidin 816

BRUNO, Ines;RICCIO, Raffaele;
1993-01-01

Abstract

Four pentacyclic guanidine derivs. [crambescidin 800 (I), crambescidin 816 (II), isocrambescidin 800 (III), and crambidine (IV), related to ptilomycalin A] have been isolated from the Mediterranean sponge C. crambe. III and IV are new derivs., the structures of which have been detd. on the basis of their spectral properties. The abs. configuration of II at the stereogenic center C-43 has been detd. by applying Mosher's method. Pharmacol. and biol. activities of the Crambe crambe alkaloids are reported. In particular, II was found to have a potent Ca2+ antagonist effect and to inhibit the acetylcholine-induced contraction of guinea pig ileum at very low concns.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/3128735
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 121
  • ???jsp.display-item.citation.isi??? 115
social impact