The arachidonic acid is a precursor in the synthesis of eicosanoids: through the action of cyclooxygenase and peroxidase, it gives rise to prostaglandins then is converted into different substances involved in inflammation and in many physiological reactions as protectors of gastric mucosa. The aim of this research was to verify the pharmacological activity in a new series of amides of arachidonic acid. To this end, we have been synthesized new derivatives and performed cytotoxicity studies and preliminary studies of anti-inflammatory activity. Our data indicate that some compounds are able to control the NO and PGs bio-synthesis on inflammatory process through the in vitro inhibition of iNOS activity in J744.A1 macrophage cell line.
New amides of arachidonic-acid as potential antiinflammatory drugs: A preliminary study
AUTORE, Giuseppina;MARZOCCO, STEFANIA;SATURNINO, Carmela;CAPASSO, Anna
2010-01-01
Abstract
The arachidonic acid is a precursor in the synthesis of eicosanoids: through the action of cyclooxygenase and peroxidase, it gives rise to prostaglandins then is converted into different substances involved in inflammation and in many physiological reactions as protectors of gastric mucosa. The aim of this research was to verify the pharmacological activity in a new series of amides of arachidonic acid. To this end, we have been synthesized new derivatives and performed cytotoxicity studies and preliminary studies of anti-inflammatory activity. Our data indicate that some compounds are able to control the NO and PGs bio-synthesis on inflammatory process through the in vitro inhibition of iNOS activity in J744.A1 macrophage cell line.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
