N-Mannich bases of 1-isoindolinones can be rapidly assembled by reacting 2-formylbenzonitriles with electroactivated amines on a Pt cathode, using a catalytic amount of electricity. Usefully, chiral amines allow the attainment of enantiopure N-Mannich bases by simple chromatographic separation
Quick and easy access to N-Mannich bases of 1-isoindolinones by catalytic electroactivation of primary and secondary amines and tandem reaction with 2-formylbenzonitriles
PALOMBI, Laura;DI MOLA, ANTONIA;MASSA, Antonio
2015-01-01
Abstract
N-Mannich bases of 1-isoindolinones can be rapidly assembled by reacting 2-formylbenzonitriles with electroactivated amines on a Pt cathode, using a catalytic amount of electricity. Usefully, chiral amines allow the attainment of enantiopure N-Mannich bases by simple chromatographic separationFile in questo prodotto:
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