We report a new potent revisited version of a triazole-based inhibitor obtained by structure-based drug design on the human mPGES-1 crystal structure. Moreover, we disclosed the substitution with a halogen atom at position 5 as a new key factor influencing the biological activity on the mPGES-1 enzyme
Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors
CHINI, MARIA GIOVANNA;CANTONE, VINCENZA;BRUNO, Ines;RICCIO, Raffaele;BIFULCO, Giuseppe
2015-01-01
Abstract
We report a new potent revisited version of a triazole-based inhibitor obtained by structure-based drug design on the human mPGES-1 crystal structure. Moreover, we disclosed the substitution with a halogen atom at position 5 as a new key factor influencing the biological activity on the mPGES-1 enzymeFile in questo prodotto:
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