Production of polyaspartamide based nanovectors by the method of solvent evaporation from ultrasound-made multiple emulsions

A method based on the solvent evaporation from multiple emulsions, obtained by using ultrasonic energy, was developed to produce biocompatible nanovectors. Firstly, the possibility to apply an unified preparation technique to different polymers was explored by using two commercial polymers, i.e. polycaprolactone (PCL) and polylactic acid (PLA), and a purposely synthetized random co-polymer of poly(DL-lactide-co-caprolactone) 70/30 (PLA-CL 70/30), encapsulating α tocopherol (TC), as lipophilic model molecule. Then, the novel amphiphilic copolymer, the α,β-poly (N-2-hydroxyethyl)-DLaspartamide- polylactic acid (PHEA - PLA) was prepared towards the encapsulation of hydrophobic molecules. In this work, this latter copolymer was used to prove the rapid adaptability of the multiple emulsions technique previously developed with the aim to produce biocompatible nanoparticles with high drug encapsulation efficiency, to use for long term release drug delivery systems.