RUGGIERO, DAFNE
RUGGIERO, DAFNE
Dipartimento di Farmacia/DIFARMA
A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4-Thiazolidinedione-Based Molecules as New Dual mPGES-1/5-LO Inhibitors
2020 Lauro, G.; Terracciano, S.; Cantone, V.; Ruggiero, D.; Fischer, K.; Pace, S.; Werz, O.; Bruno, I.; Bifulco, G.
A multidisciplinary functional proteomics-aided strategy as a tool for the profiling of a novel cytotoxic thiadiazolopyrimidone
2023 Morretta, Elva; Ruggiero, Dafne; Belvedere, Raffaella; Petrella, Antonello; Bruno, Ines; Terracciano, Stefania; Monti, Maria Chiara
Chemoproteomics Reveals USP5 (Ubiquitin Carboxyl-Terminal Hydrolase 5) as Promising Target of the Marine Polyketide Gracilioether A
2024 Capuano, A.; D'Urso, G.; Aliberti, M.; Ruggiero, D.; Terracciano, S.; Festa, C.; Tosco, A.; Chini, M. G.; Lauro, G.; Bifulco, G.; Casapullo, A.
Discovery of noscapine derivatives as potential β-tubulin inhibitors
2020 Nemati, F.; Salehi, P.; Bararjanian, M.; Hadian, N.; Mohebbi, M.; Lauro, G.; Ruggiero, D.; Terracciano, S.; Bifulco, G.; Bruno, I.
Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors
2018 DI MICCO, Simone; Luana, Pulvirenti; Bruno, Ines; Terracciano, Stefania; Russo, Alessandra; Vaccaro, Mariacarmela; Ruggiero, Dafne; Vera, Muccilli; Nunzio, Cardullo; Corrado, Tringali; Riccio, Raffaele; Bifulco, Giuseppe
Identification of 2,4,5-trisubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one-based small molecules as selective BRD9 binders
2023 Colarusso, Ester; Ceccacci, Sara; Monti, Maria Chiara; Gazzillo, Erica; Giordano, Assunta; Chini, Maria Giovanna; Ferraro, Maria Grazia; Piccolo, Marialuisa; Ruggiero, Dafne; Irace, Carlo; Terracciano, Stefania; Bruno, Ines; Bifulco, Giuseppe; Lauro, Gianluigi
Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition
2021 Di Micco, S.; Terracciano, S.; Ruggiero, D.; Potenza, M.; Vaccaro, M. C.; Fischer, K.; Werz, O.; Bruno, I.; Bifulco, G.
Identification of a New Promising BAG3 Modulator Featuring the Imidazopyridine Scaffold
2024 Ruggiero, D.; Ingenito, E.; Boccia, E.; Vestuto, V.; Miranda, M. R.; Terracciano, S.; Lauro, G.; Bifulco, G.; Bruno, I.
Identification of Honokiol-Based Scaffold to Design Tankyrase 1/2 Inhibitors by In Silico and In Vitro Studies
2024 Di Micco, S.; Ruggiero, D.; Terracciano, S.; Bruno, I.; Cardullo, N.; Muccilli, V.; Tringali, C.; Bifulco, G.
Identification of the first-in-class dual inhibitor targeting BAG3 and HSP70 proteins to disrupt multiple chaperone pathways
2025 Ruggiero, Dafne; Ingenito, Emis; Boccia, Eleonora; Vestuto, Vincenzo; D'Urso, Gilda; Capuano, Alessandra; Casapullo, Agostino; Terracciano, Stefania; Bifulco, Giuseppe; Lauro, Gianluigi; Bruno, Ines
In Silico Design, Chemical Synthesis, Biophysical and in Vitro Evaluation for the Identification of 1-Ethyl-1H-Pyrazolo[3,4-b]Pyridine-Based BRD9 Binders
2024 Colarusso, E.; Gazzillo, E.; Pierri, M.; Ruggiero, D.; Chini, M. G.; Bruno, I.; Bifulco, G.; Terracciano, S.; Lauro, G.
Protein Preparation Automatic Protocol for High-Throughput Inverse Virtual Screening: Accelerating the Target Identification by Computational Methods
2019 De Vita, S.; Lauro, G.; Ruggiero, D.; Terracciano, S.; Riccio, R.; Bifulco, G.
Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation
2022 Gazzillo, Erica; Terracciano, Stefania; Ruggiero, Dafne; Potenza, Marianna; Chini, Maria Giovanna; Lauro, Gianluigi; Fischer, Katrin; Hofstetter, Robert Klaus; Giordano, Assunta; Werz, Oliver; Bruno, Ines; Bifulco, Giuseppe
Structural Refinement of 2,4-Thiazolidinedione Derivatives as New Anticancer Agents Able to Modulate the BAG3 Protein
2022 Ruggiero, D.; Terracciano, S.; Lauro, G.; Pecoraro, M.; Franceschelli, S.; Bifulco, G.; Bruno, I.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4-Thiazolidinedione-Based Molecules as New Dual mPGES-1/5-LO Inhibitors | 1-gen-2020 | Lauro, G.; Terracciano, S.; Cantone, V.; Ruggiero, D.; Fischer, K.; Pace, S.; Werz, O.; Bruno, I.; Bifulco, G. | |
| A multidisciplinary functional proteomics-aided strategy as a tool for the profiling of a novel cytotoxic thiadiazolopyrimidone | 1-gen-2023 | Morretta, Elva; Ruggiero, Dafne; Belvedere, Raffaella; Petrella, Antonello; Bruno, Ines; Terracciano, Stefania; Monti, Maria Chiara | |
| Chemoproteomics Reveals USP5 (Ubiquitin Carboxyl-Terminal Hydrolase 5) as Promising Target of the Marine Polyketide Gracilioether A | 1-gen-2024 | Capuano, A.; D'Urso, G.; Aliberti, M.; Ruggiero, D.; Terracciano, S.; Festa, C.; Tosco, A.; Chini, M. G.; Lauro, G.; Bifulco, G.; Casapullo, A. | |
| Discovery of noscapine derivatives as potential β-tubulin inhibitors | 1-gen-2020 | Nemati, F.; Salehi, P.; Bararjanian, M.; Hadian, N.; Mohebbi, M.; Lauro, G.; Ruggiero, D.; Terracciano, S.; Bifulco, G.; Bruno, I. | |
| Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors | 1-gen-2018 | DI MICCO, Simone; Luana, Pulvirenti; Bruno, Ines; Terracciano, Stefania; Russo, Alessandra; Vaccaro, Mariacarmela; Ruggiero, Dafne; Vera, Muccilli; Nunzio, Cardullo; Corrado, Tringali; Riccio, Raffaele; Bifulco, Giuseppe | |
| Identification of 2,4,5-trisubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one-based small molecules as selective BRD9 binders | 1-gen-2023 | Colarusso, Ester; Ceccacci, Sara; Monti, Maria Chiara; Gazzillo, Erica; Giordano, Assunta; Chini, Maria Giovanna; Ferraro, Maria Grazia; Piccolo, Marialuisa; Ruggiero, Dafne; Irace, Carlo; Terracciano, Stefania; Bruno, Ines; Bifulco, Giuseppe; Lauro, Gianluigi | |
| Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition | 1-gen-2021 | Di Micco, S.; Terracciano, S.; Ruggiero, D.; Potenza, M.; Vaccaro, M. C.; Fischer, K.; Werz, O.; Bruno, I.; Bifulco, G. | |
| Identification of a New Promising BAG3 Modulator Featuring the Imidazopyridine Scaffold | 1-gen-2024 | Ruggiero, D.; Ingenito, E.; Boccia, E.; Vestuto, V.; Miranda, M. R.; Terracciano, S.; Lauro, G.; Bifulco, G.; Bruno, I. | |
| Identification of Honokiol-Based Scaffold to Design Tankyrase 1/2 Inhibitors by In Silico and In Vitro Studies | 1-gen-2024 | Di Micco, S.; Ruggiero, D.; Terracciano, S.; Bruno, I.; Cardullo, N.; Muccilli, V.; Tringali, C.; Bifulco, G. | |
| Identification of the first-in-class dual inhibitor targeting BAG3 and HSP70 proteins to disrupt multiple chaperone pathways | 1-gen-2025 | Ruggiero, Dafne; Ingenito, Emis; Boccia, Eleonora; Vestuto, Vincenzo; D'Urso, Gilda; Capuano, Alessandra; Casapullo, Agostino; Terracciano, Stefania; Bifulco, Giuseppe; Lauro, Gianluigi; Bruno, Ines | |
| In Silico Design, Chemical Synthesis, Biophysical and in Vitro Evaluation for the Identification of 1-Ethyl-1H-Pyrazolo[3,4-b]Pyridine-Based BRD9 Binders | 1-gen-2024 | Colarusso, E.; Gazzillo, E.; Pierri, M.; Ruggiero, D.; Chini, M. G.; Bruno, I.; Bifulco, G.; Terracciano, S.; Lauro, G. | |
| Protein Preparation Automatic Protocol for High-Throughput Inverse Virtual Screening: Accelerating the Target Identification by Computational Methods | 1-gen-2019 | De Vita, S.; Lauro, G.; Ruggiero, D.; Terracciano, S.; Riccio, R.; Bifulco, G. | |
| Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation | 1-gen-2022 | Gazzillo, Erica; Terracciano, Stefania; Ruggiero, Dafne; Potenza, Marianna; Chini, Maria Giovanna; Lauro, Gianluigi; Fischer, Katrin; Hofstetter, Robert Klaus; Giordano, Assunta; Werz, Oliver; Bruno, Ines; Bifulco, Giuseppe | |
| Structural Refinement of 2,4-Thiazolidinedione Derivatives as New Anticancer Agents Able to Modulate the BAG3 Protein | 1-gen-2022 | Ruggiero, D.; Terracciano, S.; Lauro, G.; Pecoraro, M.; Franceschelli, S.; Bifulco, G.; Bruno, I. |