CIPRIANO, ALESSANDRA
CIPRIANO, ALESSANDRA
Dipartimento di Farmacia/DIFARMA
A combined approach of structure-based virtual screening and NMR to interrupt the PD-1/PD-L1 axis: Biphenyl-benzimidazole containing compounds as novel PD-L1 inhibitors
2023-01-01 Donati, Greta; Viviano, Monica; D'Amore, Vincenzo Maria; Cipriano, Alessandra; Diakogiannaki, Isidora; Amato, Jussara; Tomassi, Stefano; Brancaccio, Diego; Russomanno, Pasquale; Di Leva, Francesco Saverio; Arosio, Daniela; Seneci, Pierfausto; Taliani, Sabrina; Magiera-Mularz, Katarzyna; Musielak, Bogdan; Skalniak, Lukasz; Holak, Tad A; Castellano, Sabrina; La Pietra, Valeria; Marinelli, Luciana
Design, synthesis and in vitro evaluation of bivalent chemical probes for bromo and extra-terminal domain (BET) proteins
2017-01-01 Cipriano, Alessandra; Milite, Ciro; Panagis, Filippakopoulos; Castellano, Sabrina; Sbardella, Gianluca
Discovery of a novel chemotype of histone lysine methyltransferase EHMT1/2 (GLP/G9a) inhibitors: rational design, synthesis, biological evaluation and co-crystal structure
2019-01-01 Milite, Ciro; Feoli, Alessandra; Horton, John R; Rescigno, Donatella; Cipriano, Alessandra; Pisapia, Vincenzo; Viviano, Monica; Pepe, Giacomo; Amendola, Giorgio; Novellino, Ettore; Cosconati, Sandro; Cheng, Xiaodong; Castellano, Sabrina; Sbardella, Gianluca
Discovery of benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain
2022-01-01 Cipriano, Alessandra; Milite, Ciro; Feoli, Alessandra; Viviano, Monica; Pepe, Giacomo; Campiglia, Pietro; Sarno, Giuliana; Picaud, Sarah; Imaide, Satomi; Makukhin, Nikolai; Filippakopoulos, Panagis; Ciulli, Alessio; Castellano, Sabrina; Sbardella, Gianluca
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
2023-01-01 Feoli, Alessandra; Iannelli, Giulia; Cipriano, Alessandra; Milite, Ciro; Shen, Lei; Wang, Zhihao; Hadjikyriacou, Andrea; Lowe, Troy L; Safaeipour, Cyrus; Viviano, Monica; Sarno, Giuliana; Morretta, Elva; Monti, Maria Chiara; Yang, Yanzhong; Clarke, Steven G; Cosconati, Sandro; Castellano, Sabrina; Sbardella, Gianluca
Lysine methyltransferase inhibitors: where we are now.
2022-01-01 Feoli, Alessandra; Viviano, Monica; Cipriano, Alessandra; Milite, Ciro; Castellano, Sabrina; Sbardella, Gianluca
NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors
2023-01-01 Cipriano, Alessandra; Viviano, Monica; Feoli, Alessandra; Milite, Ciro; Sarno, Giuliana; Castellano, Sabrina; Sbardella, Gianluca
Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies
2019-01-01 Milite, C.; Amendola, G.; Nocentini, A.; Bua, S.; Cipriano, A.; Barresi, E.; Feoli, A.; Novellino, E.; Da Settimo, F.; Supuran, C. T.; Castellano, S.; Cosconati, S.; Taliani, S.
Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors
2024-01-01 Milite, Ciro; Sarno, Giuliana; Pacilio, Ida; Cianciulli, Agostino; Viviano, Monica; Iannelli, Giulia; Gazzillo, Erica; Feoli, Alessandra; Cipriano, Alessandra; Chini, Maria Giovanna; Castellano, Sabrina; Bifulco, Giuseppe; Sbardella, Gianluca
Successes and challenges in the development of BD1-selective BET inhibitors: a patent review
2024-01-01 Viviano, Monica; Cipriano, Alessandra; Fabbrizi, Emanuele; Feoli, Alessandra; Castellano, Sabrina; Sbardella, Gianluca; Mai, Antonello; Milite, Ciro; Rotili, Dante
Targeting epigenetic reader domains by chemical biology
2020-01-01 Cipriano, Alessandra; Sbardella, Gianluca; Ciulli, Alessio
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach
2022-01-01 Iannelli, Giulia; Milite, Ciro; Marechal, Nils; Cura, Vincent; Bonnefond, Luc; Troffer-Charlier, Nathalie; Feoli, Alessandra; Rescigno, Donatella; Wang, Yalong; Cipriano, Alessandra; Viviano, Monica; Bedford, Mark T; Cavarelli, Jean; Castellano, Sabrina; Sbardella, Gianluca
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A combined approach of structure-based virtual screening and NMR to interrupt the PD-1/PD-L1 axis: Biphenyl-benzimidazole containing compounds as novel PD-L1 inhibitors | 1-gen-2023 | Donati, Greta; Viviano, Monica; D'Amore, Vincenzo Maria; Cipriano, Alessandra; Diakogiannaki, Isidora; Amato, Jussara; Tomassi, Stefano; Brancaccio, Diego; Russomanno, Pasquale; Di Leva, Francesco Saverio; Arosio, Daniela; Seneci, Pierfausto; Taliani, Sabrina; Magiera-Mularz, Katarzyna; Musielak, Bogdan; Skalniak, Lukasz; Holak, Tad A; Castellano, Sabrina; La Pietra, Valeria; Marinelli, Luciana | |
| Design, synthesis and in vitro evaluation of bivalent chemical probes for bromo and extra-terminal domain (BET) proteins | 1-gen-2017 | Cipriano, Alessandra; Milite, Ciro; Panagis, Filippakopoulos; Castellano, Sabrina; Sbardella, Gianluca | |
| Discovery of a novel chemotype of histone lysine methyltransferase EHMT1/2 (GLP/G9a) inhibitors: rational design, synthesis, biological evaluation and co-crystal structure | 1-gen-2019 | Milite, Ciro; Feoli, Alessandra; Horton, John R; Rescigno, Donatella; Cipriano, Alessandra; Pisapia, Vincenzo; Viviano, Monica; Pepe, Giacomo; Amendola, Giorgio; Novellino, Ettore; Cosconati, Sandro; Cheng, Xiaodong; Castellano, Sabrina; Sbardella, Gianluca | |
| Discovery of benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain | 1-gen-2022 | Cipriano, Alessandra; Milite, Ciro; Feoli, Alessandra; Viviano, Monica; Pepe, Giacomo; Campiglia, Pietro; Sarno, Giuliana; Picaud, Sarah; Imaide, Satomi; Makukhin, Nikolai; Filippakopoulos, Panagis; Ciulli, Alessio; Castellano, Sabrina; Sbardella, Gianluca | |
| Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor | 1-gen-2023 | Feoli, Alessandra; Iannelli, Giulia; Cipriano, Alessandra; Milite, Ciro; Shen, Lei; Wang, Zhihao; Hadjikyriacou, Andrea; Lowe, Troy L; Safaeipour, Cyrus; Viviano, Monica; Sarno, Giuliana; Morretta, Elva; Monti, Maria Chiara; Yang, Yanzhong; Clarke, Steven G; Cosconati, Sandro; Castellano, Sabrina; Sbardella, Gianluca | |
| Lysine methyltransferase inhibitors: where we are now. | 1-gen-2022 | Feoli, Alessandra; Viviano, Monica; Cipriano, Alessandra; Milite, Ciro; Castellano, Sabrina; Sbardella, Gianluca | |
| NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors | 1-gen-2023 | Cipriano, Alessandra; Viviano, Monica; Feoli, Alessandra; Milite, Ciro; Sarno, Giuliana; Castellano, Sabrina; Sbardella, Gianluca | |
| Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies | 1-gen-2019 | Milite, C.; Amendola, G.; Nocentini, A.; Bua, S.; Cipriano, A.; Barresi, E.; Feoli, A.; Novellino, E.; Da Settimo, F.; Supuran, C. T.; Castellano, S.; Cosconati, S.; Taliani, S. | |
| Prodrug Approach to Exploit (S) Alanine as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors | 1-gen-2024 | Milite, Ciro; Sarno, Giuliana; Pacilio, Ida; Cianciulli, Agostino; Viviano, Monica; Iannelli, Giulia; Gazzillo, Erica; Feoli, Alessandra; Cipriano, Alessandra; Chini, Maria Giovanna; Castellano, Sabrina; Bifulco, Giuseppe; Sbardella, Gianluca | |
| Successes and challenges in the development of BD1-selective BET inhibitors: a patent review | 1-gen-2024 | Viviano, Monica; Cipriano, Alessandra; Fabbrizi, Emanuele; Feoli, Alessandra; Castellano, Sabrina; Sbardella, Gianluca; Mai, Antonello; Milite, Ciro; Rotili, Dante | |
| Targeting epigenetic reader domains by chemical biology | 1-gen-2020 | Cipriano, Alessandra; Sbardella, Gianluca; Ciulli, Alessio | |
| Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach | 1-gen-2022 | Iannelli, Giulia; Milite, Ciro; Marechal, Nils; Cura, Vincent; Bonnefond, Luc; Troffer-Charlier, Nathalie; Feoli, Alessandra; Rescigno, Donatella; Wang, Yalong; Cipriano, Alessandra; Viviano, Monica; Bedford, Mark T; Cavarelli, Jean; Castellano, Sabrina; Sbardella, Gianluca |