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EnglishRecent data have paved the way to mechanistic studies into the role of Tbx1 during development. Tbx1 is haploinsufficient and is involved in an important genetic disorder. The gene encodes a T-box transcription factor that is expressed from approximately E7.5 in mouse embryos and continues to be expressed in a highly dynamic manner. It is neither a strong transcriptional activator nor a strong repressor, but it regulates a large number of genes through epigenetic modifications. Here, we review recent literature concerning mechanisms of gene regulation by Tbx1 and its role in mammalian development, with a special focus on the cardiac, vascular, and central nervous systems.
| Titolo: | Tbx1: Transcriptional and Developmental Functions | |
| Autori: | ||
| Data di pubblicazione: | 2017 | |
| Handle: | http://hdl.handle.net/11386/4684412 | |
| Appare nelle tipologie: | 2.1.1 Articolo su libro con DOI |
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