Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca(2+)) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca(2+) handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.
New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling
GAMBARDELLA, JESSICA;IACCARINO, Guido;
2017-01-01
Abstract
Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca(2+)) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca(2+) handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.File in questo prodotto:
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