A convenient way for the achievement of polymer-based solid materials for specific biomedical applications is grafting the appropriate macromolecules onto the surfaces in order to confer them specific properties. To date many approaches have been used to covalently modify polymeric surfaces, and among them chemoselective coupling reactions, usually referred as “click” reactions, gained much attention thanks to simple procedure with high reaction rate under mild reaction conditions (at normal temperature and pressure). In particular, radical-initiated thiol-yne “photo-click” chemistry has been demonstrated as an effective way to functionalize efficiently surfaces. In this frame, copper catalysed “click” chemistry was recently used to confer antibacterial and antibiofilm properties to propargylated PLA surfaces by immobilization of polyquaternary ammoniums.
FUNCTIONALITATION OF HYDROPHOBIC SURFACES WITH A POLYASPARTAMIDE-BASED DERIVATIVE FOR BIOMEDICAL APPLICATION
Sardo C;Cavallaro G;
2013
Abstract
A convenient way for the achievement of polymer-based solid materials for specific biomedical applications is grafting the appropriate macromolecules onto the surfaces in order to confer them specific properties. To date many approaches have been used to covalently modify polymeric surfaces, and among them chemoselective coupling reactions, usually referred as “click” reactions, gained much attention thanks to simple procedure with high reaction rate under mild reaction conditions (at normal temperature and pressure). In particular, radical-initiated thiol-yne “photo-click” chemistry has been demonstrated as an effective way to functionalize efficiently surfaces. In this frame, copper catalysed “click” chemistry was recently used to confer antibacterial and antibiofilm properties to propargylated PLA surfaces by immobilization of polyquaternary ammoniums.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
