The identification of natural products (NPs) target proteins is pivotal to understand their mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years, affinity chromatography-coupled to mass spectrometry (AP-MS) has been the top-choice technique in the Drug Target Deconvolution field, having brought brilliant results in the targetome profiling of a multitude of bioactive compounds. Unfortunately, since a chemical modification of the molecule to be investigated is mandatory, AP MS is not suitable for compounds that do not exhibit properly reactive structural feature. .. [edited by the Author]
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform / Elva Morretta , 2020 Oct 24., Anno Accademico 2018 - 2019. [10.14273/unisa-4644].
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform
Morretta, Elva
2020
Abstract
The identification of natural products (NPs) target proteins is pivotal to understand their mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years, affinity chromatography-coupled to mass spectrometry (AP-MS) has been the top-choice technique in the Drug Target Deconvolution field, having brought brilliant results in the targetome profiling of a multitude of bioactive compounds. Unfortunately, since a chemical modification of the molecule to be investigated is mandatory, AP MS is not suitable for compounds that do not exhibit properly reactive structural feature. .. [edited by the Author]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
