Design, synthesis and biological studies of novel heterocyclic compounds as anticancer drugs

Heterocyles are an essencial class of molecules, assuming a role in many aspect ofour life. Indeed heterocyclic nucleus is a common feature of several biomolecule andbioactive compounds including agrochemical products and drugs.In this work we focused on two important class of heterocyclic compounds:carbazoles and NHCs (N-heterocyclic carbenes).Carbazoles, prevalent as structural motifs in various synthetic materials andnaturally occurring alkaloids, as is known, have many applications such asoptoelectronic materials, conducting polymers and especially as promising bioactivecompounds due to their biological properties, known since 1965.Furthermore NHCs are a class of stable carbenes that over the last few years haveentered the field as "new" ligands for bioactive coordination compounds. It has beendemonstrated that metal NHC complexes can be used to develop highly efficientmetal based drugs with possible applications in the treatment of cancer or infectiousdiseases.We aimed to design, synthesize and characterize novel carbazole derivatives andNHC metal complexes with the purpose of identify new biologically activeheterocyclic compounds. [edited by Author]