PACE, Simona
PACE, Simona
Dipartimento di Farmacia/DIFARMA
5α-dihydrotestosterone abrogates sex bias in asthma like features in the mouse
2020-01-01 Cerqua, Ida; Terlizzi, Michela; Bilancia, Rossella; A Riemma, Maria; Citi, Valentina; Martelli, Alma; Pace, Simona; Spaziano, Giuseppe; D'Agostino, Bruno; Werz, Oliver; Ialenti, Armando; Sorrentino, Rosalinda; Cirino, Giuseppe; Rossi, Antonietta; Roviezzo, Fiorentina
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity
2013-01-01 Battilocchio, Claudio; Poce, Giovanna; Alfonso, Salvatore; Porretta, Giulio Cesare; Consalvi, Sara; Sautebin, Lidia; Pace, Simona; Rossi, Antonietta; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Schenone, Silvia; Giordani, Antonio; Di Francesco, Luigia; Patrignani, Paola; Biava, Mariangela
A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4-Thiazolidinedione-Based Molecules as New Dual mPGES-1/5-LO Inhibitors
2020-01-01 Lauro, G.; Terracciano, S.; Cantone, V.; Ruggiero, D.; Fischer, K.; Pace, S.; Werz, O.; Bruno, I.; Bifulco, G.
A Comprehensive In Vitro Characterization of a New Class of Indole-Based Compounds Developed as Selective Haspin Inhibitors
2024-01-01 Vestuto, Vincenzo; Ciaglia, Tania; Musella, Simona; Di Sarno, Veronica; Smaldone, Gerardina; Di Matteo, Francesca; Scala, Maria Carmina; Napolitano, Valeria; Miranda, Maria Rosaria; Amodio, Giuseppina; Novi, Sara; Pepe, Giacomo; Basilicata, Manuela Giovanna; Gazzillo, Erica; Pace, Simona; Gomez-Monterrey, Isabel M.; Sala, Marina; Bifulco, Giuseppe; Tecce, Mario Felice; Campiglia, Pietro; Ostacolo, Carmine; Lauro, Gianluigi; Manfra, Michele; Bertamino, Alessia
Aging drives organ-specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice
2021-01-01 Schädel, Patrick; Troisi, Fabiana; Czapka, Anna; Gebert, Nadja; Pace, Simona; Ori, Alessandro; Werz, Oliver
Allosteric Activation of 15-Lipoxygenase-1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation
2023-01-01 Börner, Friedemann; Pace, Simona; Jordan, Paul M; Gerstmeier, Jana; Gomez, Mario; Rossi, Antonietta; Gilbert, Nathaniel C; Newcomer, Marcia E; Werz, Oliver
Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males
2017-01-01 Pace, Simona; Pergola, Carlo; Dehm, Friederike; Rossi, Antonietta; Gerstmeier, Jana; Troisi, Fabiana; Pein, Helmut; Schaible, Anja M; Weinigel, Christina; Rummler, Silke; Northoff, Hinnak; Laufer, Stefan; Maier, Thorsten J; Rådmark, Olof; Samuelsson, Bengt; Koeberle, Andreas; Sautebin, Lidia; Werz, Oliver
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators
2021-01-01 Pace, Simona; Zhang, Kehong; Jordan, Paul M; Bilancia, Rossella; Wang, Wenfei; Börner, Friedemann; Hofstetter, Robert K; Potenza, Marianna; Kretzer, Christian; Gerstmeier, Jana; Fischer, Dagmar; Lorkowski, Stefan; Gilbert, Nathaniel C; Newcomer, Marcia E; Rossi, Antonietta; Chen, Xinchun; Werz, Oliver
Beneficial Modulation of Lipid Mediator Biosynthesis in Innate Immune Cells by Antirheumatic Tripterygium wilfordii Glycosides
2021-01-01 Zhang, Kehong; Pace, Simona; Jordan, Paul M; Peltner, Lukas K; Weber, Alexander; Fischer, Dagmar; Hofstetter, Robert K; Chen, Xinchun; Werz, Oliver
Bioactivity and Mode of Action of Bacterial Tetramic Acids
2019-01-01 Klapper, Martin; Paschold, André; Zhang, Shuaibing; Weigel, Christiane; Dahse, Hans-Martin; Götze, Sebastian; Pace, Simona; König, Stefanie; Rao, Zhigang; Reimer, Lisa; Werz, Oliver; Stallforth, Pierre
BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly
2016-01-01 Garscha, Ulrike; Voelker, Susanna; Pace, Simona; Gerstmeier, Jana; Emini, Besa; Liening, Stefanie; Rossi, Antonietta; Weinigel, Christina; Rummler, Silke; Schubert, Ulrich S; Scriba, Gerhard K E; Çelikoğlu, Erşan; Çalışkan, Burcu; Banoglu, Erden; Sautebin, Lidia; Werz, Oliver
Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis
2020-01-01 Werner, Markus; Pace, Simona; Czapka, Anna; Jordan, Paul M; Gerstmeier, Jana; Koeberle, Andreas; Werz, Oliver
Differential role of vacuolar (H+)-ATPase in the expression and activity of cyclooxygenase-2 in human monocytes
2020-01-01 Rao, Zhigang; Jordan, Paul M; Wang, Yan; Menche, Dirk; Pace, Simona; Gerstmeier, Jana; Werz, Oliver
Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization
2022-01-01 Cerqua, Ida; Musella, Simona; Peltner, Lukas Klaus; D'Avino, Danilo; Di Sarno, Veronica; Granato, Elisabetta; Vestuto, Vincenzo; Di Matteo, Rita; Pace, Simona; Ciaglia, Tania; Bilancia, Rossella; Smaldone, Gerardina; Di Matteo, Francesca; Di Micco, Simone; Bifulco, Giuseppe; Pepe, Giacomo; Basilicata, Manuela Giovanna; Rodriquez, Manuela; Gomez-Monterrey, Isabel M; Campiglia, Pietro; Ostacolo, Carmine; Roviezzo, Fiorentina; Werz, Oliver; Rossi, Antonietta; Bertamino, Alessia
Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation
2018-01-01 Cheung, Sun-Yee; Werner, Markus; Esposito, Lucia; Troisi, Fabiana; Cantone, Vincenza; Liening, Stefanie; König, Stefanie; Gerstmeier, Jana; Koeberle, Andreas; Bilancia, Rossella; Rizza, Roberta; Rossi, Antonietta; Roviezzo, Fiorentina; Temml, Veronika; Schuster, Daniela; Stuppner, Hermann; Schubert-Zsilavecz, Manfred; Werz, Oliver; Hanke, Thomas; Pace, Simona
Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs. sunflower oil
2018-01-01 Dawczynski, C; Dittrich, M; Neumann, T; Goetze, K; Welzel, A; Oelzner, P; Völker, S; Schaible, A M; Troisi, F; Thomas, L; Pace, S; Koeberle, A; Werz, O; Schlattmann, P; Lorkowski, S; Jahreis, G
Editorial: Role of Blood Cells in Inflammatory and Vascular Disorders
2020-01-01 Brancaleone, Vincenzo; Dalli, Jesmond; d'Emmanuele di Villa Bianca, Roberta; Pace, Simona
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase
2018-01-01 Pein, Helmut; Ville, Alexia; Pace, Simona; Temml, Veronika; Garscha, Ulrike; Raasch, Martin; Alsabil, Khaled; Viault, Guillaume; Dinh, Chau-Phi; Guilet, David; Troisi, Fabiana; Neukirch, Konstantin; König, Stefanie; Bilancia, Rosella; Waltenberger, Birgit; Stuppner, Hermann; Wallert, Maria; Lorkowski, Stefan; Weinigel, Christina; Rummler, Silke; Birringer, Marc; Roviezzo, Fiorentina; Sautebin, Lidia; Helesbeux, Jean-Jacques; Séraphin, Denis; Mosig, Alexander S; Schuster, Daniela; Rossi, Antonietta; Richomme, Pascal; Werz, Oliver; Koeberle, Andreas
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones
2017-01-01 Svouraki, Alexandra; Garscha, Ulrike; Kouloura, Eirini; Pace, Simona; Pergola, Carlo; Krauth, Verena; Rossi, Antonietta; Sautebin, Lidia; Halabalaki, Maria; Werz, Oliver; Gaboriaud-Kolar, Nicolas; Skaltsounis, Alexios-Leandros
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation
2021-01-01 Neukirch, Konstantin; Alsabil, Khaled; Dinh, Chau-Phi; Bilancia, Rossella; Raasch, Martin; Ville, Alexia; Cerqua, Ida; Viault, Guillaume; Bréard, Dimitri; Pace, Simona; Temml, Veronika; Brunner, Elena; Jordan, Paul M; Marques, Marta C; Loeser, Konstantin; Gollowitzer, André; Permann, Stephan; Gerstmeier, Jana; Lorkowski, Stefan; Stuppner, Hermann; Garscha, Ulrike; Rodrigues, Tiago; Bernardes, Gonçalo J L; Schuster, Daniela; Séraphin, Denis; Richomme, Pascal; Rossi, Antonietta; Mosig, Alexander S; Roviezzo, Fiorentina; Werz, Oliver; Helesbeux, Jean-Jacques; Koeberle, Andreas
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 5α-dihydrotestosterone abrogates sex bias in asthma like features in the mouse | 1-gen-2020 | Cerqua, Ida; Terlizzi, Michela; Bilancia, Rossella; A Riemma, Maria; Citi, Valentina; Martelli, Alma; Pace, Simona; Spaziano, Giuseppe; D'Agostino, Bruno; Werz, Oliver; Ialenti, Armando; Sorrentino, Rosalinda; Cirino, Giuseppe; Rossi, Antonietta; Roviezzo, Fiorentina | |
| A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity | 1-gen-2013 | Battilocchio, Claudio; Poce, Giovanna; Alfonso, Salvatore; Porretta, Giulio Cesare; Consalvi, Sara; Sautebin, Lidia; Pace, Simona; Rossi, Antonietta; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Schenone, Silvia; Giordani, Antonio; Di Francesco, Luigia; Patrignani, Paola; Biava, Mariangela | |
| A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4-Thiazolidinedione-Based Molecules as New Dual mPGES-1/5-LO Inhibitors | 1-gen-2020 | Lauro, G.; Terracciano, S.; Cantone, V.; Ruggiero, D.; Fischer, K.; Pace, S.; Werz, O.; Bruno, I.; Bifulco, G. | |
| A Comprehensive In Vitro Characterization of a New Class of Indole-Based Compounds Developed as Selective Haspin Inhibitors | 1-gen-2024 | Vestuto, Vincenzo; Ciaglia, Tania; Musella, Simona; Di Sarno, Veronica; Smaldone, Gerardina; Di Matteo, Francesca; Scala, Maria Carmina; Napolitano, Valeria; Miranda, Maria Rosaria; Amodio, Giuseppina; Novi, Sara; Pepe, Giacomo; Basilicata, Manuela Giovanna; Gazzillo, Erica; Pace, Simona; Gomez-Monterrey, Isabel M.; Sala, Marina; Bifulco, Giuseppe; Tecce, Mario Felice; Campiglia, Pietro; Ostacolo, Carmine; Lauro, Gianluigi; Manfra, Michele; Bertamino, Alessia | |
| Aging drives organ-specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice | 1-gen-2021 | Schädel, Patrick; Troisi, Fabiana; Czapka, Anna; Gebert, Nadja; Pace, Simona; Ori, Alessandro; Werz, Oliver | |
| Allosteric Activation of 15-Lipoxygenase-1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation | 1-gen-2023 | Börner, Friedemann; Pace, Simona; Jordan, Paul M; Gerstmeier, Jana; Gomez, Mario; Rossi, Antonietta; Gilbert, Nathaniel C; Newcomer, Marcia E; Werz, Oliver | |
| Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males | 1-gen-2017 | Pace, Simona; Pergola, Carlo; Dehm, Friederike; Rossi, Antonietta; Gerstmeier, Jana; Troisi, Fabiana; Pein, Helmut; Schaible, Anja M; Weinigel, Christina; Rummler, Silke; Northoff, Hinnak; Laufer, Stefan; Maier, Thorsten J; Rådmark, Olof; Samuelsson, Bengt; Koeberle, Andreas; Sautebin, Lidia; Werz, Oliver | |
| Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators | 1-gen-2021 | Pace, Simona; Zhang, Kehong; Jordan, Paul M; Bilancia, Rossella; Wang, Wenfei; Börner, Friedemann; Hofstetter, Robert K; Potenza, Marianna; Kretzer, Christian; Gerstmeier, Jana; Fischer, Dagmar; Lorkowski, Stefan; Gilbert, Nathaniel C; Newcomer, Marcia E; Rossi, Antonietta; Chen, Xinchun; Werz, Oliver | |
| Beneficial Modulation of Lipid Mediator Biosynthesis in Innate Immune Cells by Antirheumatic Tripterygium wilfordii Glycosides | 1-gen-2021 | Zhang, Kehong; Pace, Simona; Jordan, Paul M; Peltner, Lukas K; Weber, Alexander; Fischer, Dagmar; Hofstetter, Robert K; Chen, Xinchun; Werz, Oliver | |
| Bioactivity and Mode of Action of Bacterial Tetramic Acids | 1-gen-2019 | Klapper, Martin; Paschold, André; Zhang, Shuaibing; Weigel, Christiane; Dahse, Hans-Martin; Götze, Sebastian; Pace, Simona; König, Stefanie; Rao, Zhigang; Reimer, Lisa; Werz, Oliver; Stallforth, Pierre | |
| BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly | 1-gen-2016 | Garscha, Ulrike; Voelker, Susanna; Pace, Simona; Gerstmeier, Jana; Emini, Besa; Liening, Stefanie; Rossi, Antonietta; Weinigel, Christina; Rummler, Silke; Schubert, Ulrich S; Scriba, Gerhard K E; Çelikoğlu, Erşan; Çalışkan, Burcu; Banoglu, Erden; Sautebin, Lidia; Werz, Oliver | |
| Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis | 1-gen-2020 | Werner, Markus; Pace, Simona; Czapka, Anna; Jordan, Paul M; Gerstmeier, Jana; Koeberle, Andreas; Werz, Oliver | |
| Differential role of vacuolar (H+)-ATPase in the expression and activity of cyclooxygenase-2 in human monocytes | 1-gen-2020 | Rao, Zhigang; Jordan, Paul M; Wang, Yan; Menche, Dirk; Pace, Simona; Gerstmeier, Jana; Werz, Oliver | |
| Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization | 1-gen-2022 | Cerqua, Ida; Musella, Simona; Peltner, Lukas Klaus; D'Avino, Danilo; Di Sarno, Veronica; Granato, Elisabetta; Vestuto, Vincenzo; Di Matteo, Rita; Pace, Simona; Ciaglia, Tania; Bilancia, Rossella; Smaldone, Gerardina; Di Matteo, Francesca; Di Micco, Simone; Bifulco, Giuseppe; Pepe, Giacomo; Basilicata, Manuela Giovanna; Rodriquez, Manuela; Gomez-Monterrey, Isabel M; Campiglia, Pietro; Ostacolo, Carmine; Roviezzo, Fiorentina; Werz, Oliver; Rossi, Antonietta; Bertamino, Alessia | |
| Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation | 1-gen-2018 | Cheung, Sun-Yee; Werner, Markus; Esposito, Lucia; Troisi, Fabiana; Cantone, Vincenza; Liening, Stefanie; König, Stefanie; Gerstmeier, Jana; Koeberle, Andreas; Bilancia, Rossella; Rizza, Roberta; Rossi, Antonietta; Roviezzo, Fiorentina; Temml, Veronika; Schuster, Daniela; Stuppner, Hermann; Schubert-Zsilavecz, Manfred; Werz, Oliver; Hanke, Thomas; Pace, Simona | |
| Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs. sunflower oil | 1-gen-2018 | Dawczynski, C; Dittrich, M; Neumann, T; Goetze, K; Welzel, A; Oelzner, P; Völker, S; Schaible, A M; Troisi, F; Thomas, L; Pace, S; Koeberle, A; Werz, O; Schlattmann, P; Lorkowski, S; Jahreis, G | |
| Editorial: Role of Blood Cells in Inflammatory and Vascular Disorders | 1-gen-2020 | Brancaleone, Vincenzo; Dalli, Jesmond; d'Emmanuele di Villa Bianca, Roberta; Pace, Simona | |
| Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase | 1-gen-2018 | Pein, Helmut; Ville, Alexia; Pace, Simona; Temml, Veronika; Garscha, Ulrike; Raasch, Martin; Alsabil, Khaled; Viault, Guillaume; Dinh, Chau-Phi; Guilet, David; Troisi, Fabiana; Neukirch, Konstantin; König, Stefanie; Bilancia, Rosella; Waltenberger, Birgit; Stuppner, Hermann; Wallert, Maria; Lorkowski, Stefan; Weinigel, Christina; Rummler, Silke; Birringer, Marc; Roviezzo, Fiorentina; Sautebin, Lidia; Helesbeux, Jean-Jacques; Séraphin, Denis; Mosig, Alexander S; Schuster, Daniela; Rossi, Antonietta; Richomme, Pascal; Werz, Oliver; Koeberle, Andreas | |
| Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones | 1-gen-2017 | Svouraki, Alexandra; Garscha, Ulrike; Kouloura, Eirini; Pace, Simona; Pergola, Carlo; Krauth, Verena; Rossi, Antonietta; Sautebin, Lidia; Halabalaki, Maria; Werz, Oliver; Gaboriaud-Kolar, Nicolas; Skaltsounis, Alexios-Leandros | |
| Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation | 1-gen-2021 | Neukirch, Konstantin; Alsabil, Khaled; Dinh, Chau-Phi; Bilancia, Rossella; Raasch, Martin; Ville, Alexia; Cerqua, Ida; Viault, Guillaume; Bréard, Dimitri; Pace, Simona; Temml, Veronika; Brunner, Elena; Jordan, Paul M; Marques, Marta C; Loeser, Konstantin; Gollowitzer, André; Permann, Stephan; Gerstmeier, Jana; Lorkowski, Stefan; Stuppner, Hermann; Garscha, Ulrike; Rodrigues, Tiago; Bernardes, Gonçalo J L; Schuster, Daniela; Séraphin, Denis; Richomme, Pascal; Rossi, Antonietta; Mosig, Alexander S; Roviezzo, Fiorentina; Werz, Oliver; Helesbeux, Jean-Jacques; Koeberle, Andreas |