Two new furostanol saponins, (25R)-26-O-beta-D-glucopyranosyl-5 alpha-furostan-2 alpha,3 beta,22 alpha,26-tetraol 3-O-{beta-D-galactopyranosyl-(1 -> 2)-O-[-beta-xylopyranosyl-(1 -> 3)]-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyrano- side} (1) and (25R)-26-O-beta-D-glucopyranosyl-5 alpha-furostan-3 beta,22 alpha,26-triol 3-O-{beta-D-galactopyranosyl-(1 -> 2)-O-[beta-D-xylopyranosyl-(1 -> 3)]-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranoside} (2), and their O-methyl derivatives (3 and 4), and a new megastigmane glucoside, (6S,7E,9 xi)-6,9,10-trihydroxy-4,7-megastigmadien-3-one 10-O-beta-D-glucopyranoside (6), along with one known spirostanol saponin, gitonin (5), and four known megastigmane glucosides were isolated from the aerial parts of Tribulus parvispinus. Their structures were established by detailed spectroscopic analysis. The cytotoxic activities of 1-6 against U937, MCF7, and HepG2 cells were evaluated. Compounds 2 (IC50 0.5 micro M) and 5 (IC50 0.1 microM) showed the highest activity against U937 cells.

Cytotoxic Furostanol Saponins and a Megastigmane Glucoside from Tribulus parvispinus.

PERRONE, ANGELA;BELISARIO, MARIA ANTONIETTA;PIZZA, Cosimo;PIACENTE, Sonia
2005

Abstract

Two new furostanol saponins, (25R)-26-O-beta-D-glucopyranosyl-5 alpha-furostan-2 alpha,3 beta,22 alpha,26-tetraol 3-O-{beta-D-galactopyranosyl-(1 -> 2)-O-[-beta-xylopyranosyl-(1 -> 3)]-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyrano- side} (1) and (25R)-26-O-beta-D-glucopyranosyl-5 alpha-furostan-3 beta,22 alpha,26-triol 3-O-{beta-D-galactopyranosyl-(1 -> 2)-O-[beta-D-xylopyranosyl-(1 -> 3)]-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranoside} (2), and their O-methyl derivatives (3 and 4), and a new megastigmane glucoside, (6S,7E,9 xi)-6,9,10-trihydroxy-4,7-megastigmadien-3-one 10-O-beta-D-glucopyranoside (6), along with one known spirostanol saponin, gitonin (5), and four known megastigmane glucosides were isolated from the aerial parts of Tribulus parvispinus. Their structures were established by detailed spectroscopic analysis. The cytotoxic activities of 1-6 against U937, MCF7, and HepG2 cells were evaluated. Compounds 2 (IC50 0.5 micro M) and 5 (IC50 0.1 microM) showed the highest activity against U937 cells.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/1058326
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