1 Contributo su Rivista

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1.1 Articoli su Rivista 10881
1.1.1 Articolo su rivista con DOI 15965
1.1.2 Articolo su rivista con ISSN 32483
1.2 Recensione 1678
1.3 Scheda bibliografica 173
1.4 Nota a sentenza 533
1.5 Abstract su Rivista 1193
1.6 Traduzione in Rivista 184

Prodotti recenti

BRAF mutation in cytology samples as a diagnostic tool for papillary thyroid carcinoma

Introduction: Thyroid cancer is a rare disease that needs to be differentiated from the more frequent benign nodular goiter. The current, primary technique for distinguishing between benign and malignant nodules is by a fine-needle biopsy (FNB) cytological examination. This type of examination, unfortunately, often provides inconclusive results, and in recent years the introduction of molecular markers for the preoperative diagnosis of thyroid nodules has been proposed. Areas covered: This re...

Great veins invasion in follicular thyroid cancer: single-centre study assessing prevalence and clinical outcome

Purpose: Great veins invasion is considered as a rare and prognostically unfavourable event in thyroid cancer. However, current knowledge about this issue is mainly based on single case reports. Follicular thyroid cancer (FTC) represents the histotype with the most pronounced angioinvasive feature. This study is aimed at assessing the actual prevalence of great veins invasion in FTC and providing information about prognosis and the proper clinical management of these patients. Methods: Clinic...

High Growth Rate of Benign Thyroid Nodules Bearing RET/PTC Rearrangements

Context: Benign thyroid nodules display a broad range of behaviors from a stationary size to a progressive growth. The RET/PTC oncogene has been documented in a fraction of benign thyroid nodules, besides papillary thyroid carcinomas, and it might therefore influence their growth. Objective: The aim of the present work was to evaluate whether RET/PTC in benign thyroid nodules associates with a different nodular growth rate. Study Design: In this prospective multicentric study, 125 subjects wi...

Prevalence of RET/PTC rearrangement in benign and malignant thyroid nodules and its clinical application

Fine-needle aspiration cytology (FNAC) is the primary means to distinguish benign thyroid nodules from malignant ones. About 20% of FNAC yields indeterminate results leading to unnecessary or delayed surgery. Many studies of tissue samples, the majority of which are retrospective advocate testing for RET rearrangements as a diagnostic adjunctive tool in thyroid nodules with indeterminate cytological findings. Because of the uncertain prevalence of RET rearrangements, its utility as a tumor ma...

Growing thyroid nodules with benign histology and RET rearrangement

Some benign thyroid nodules are stationary in size over time while others grow progressively, indicating that there is a broad individual variability within benign nodules. To date, it is very difficult to predict if a benign thyroid nodule will grow in size and which will be its trend over time. While BRAFV600E is a highly specific marker of thyroid cancer, RET rearrangements have been disclosed also in non malignant thyroid lesions and their biological significance is debated. We compared t...

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