The synthesis of two potentially anti-inflammatory steroidal hybrid compounds has been accomplished through a 16- and 17-step sequence, respectively, starting from commercially available androst-5-en-3beta-ol-17-one. The synthetic strategies are based both onstereoselective side chains elaboration and high yielding functional group transformations.
Synthesis of potentially anti-inflammatory IPL576,092-contignasterol and IPL576,092-manoalide hybrids.
IZZO, Irene;DELLA MONICA, Carmela;CASAPULLO, Agostino;DE RICCARDIS, Francesco
2004
Abstract
The synthesis of two potentially anti-inflammatory steroidal hybrid compounds has been accomplished through a 16- and 17-step sequence, respectively, starting from commercially available androst-5-en-3beta-ol-17-one. The synthetic strategies are based both onstereoselective side chains elaboration and high yielding functional group transformations.File in questo prodotto:
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