An operationally simple and mild protocol for the catalytic enantioselective epoxidation of r,â-unsaturated ketones has been estabilished using commercially available r,r-diphenyl-L-prolinol as bifunctional organocatalyst and tert-butyl hydroperoxide (TBHP) as oxidant. The epoxides have been obtained in good yields and with up to 80% ee.
Enantioselective epoxidation of a,b-enones promoted by a,a-diphenyl-L-prolinol as bifunctional organocatalyst
LATTANZI, Alessandra
2005
Abstract
An operationally simple and mild protocol for the catalytic enantioselective epoxidation of r,â-unsaturated ketones has been estabilished using commercially available r,r-diphenyl-L-prolinol as bifunctional organocatalyst and tert-butyl hydroperoxide (TBHP) as oxidant. The epoxides have been obtained in good yields and with up to 80% ee.File in questo prodotto:
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