A mild and practical procedure of Horner-Wadsworth-Emmons olefination promoted by lithium hydroxide and alpha-cyano phosphonates has been set up for the synthesis of alpha,beta-unsaturated nitrites. The reaction conditions are tolerated by functionalized ketones and the exclusive formation of E-gamma-hydroxy alpha,beta-unsaturated nitrites has been observed.
Convenient procedure of Horner-Wadsworth-Emmons olefination for the synthesis of simple and functionalised a,b-unsaturated nitriles
LATTANZI, Alessandra;MASSA, Antonio;SCETTRI, Arrigo
2003-01-01
Abstract
A mild and practical procedure of Horner-Wadsworth-Emmons olefination promoted by lithium hydroxide and alpha-cyano phosphonates has been set up for the synthesis of alpha,beta-unsaturated nitrites. The reaction conditions are tolerated by functionalized ketones and the exclusive formation of E-gamma-hydroxy alpha,beta-unsaturated nitrites has been observed.File in questo prodotto:
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