Chemical investigation of the Et2O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure bisindole alkaloids (1-13). Compounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human broncopulmonary cancer cells (NSCLC-N6) with an IC50 of 12 and 6.3 íg/mL, respectively
Titolo: | New Bisindole Alkaloids of the Topsentin and Hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei. |
Autori: | |
Data di pubblicazione: | 2000 |
Rivista: | |
Handle: | http://hdl.handle.net/11386/1065334 |
Appare nelle tipologie: | 1.1.2 Articolo su rivista con ISSN |
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