Chemical investigation of the Et2O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure bisindole alkaloids (1-13). Compounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human broncopulmonary cancer cells (NSCLC-N6) with an IC50 of 12 and 6.3 íg/mL, respectively

New Bisindole Alkaloids of the Topsentin and Hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei.

CASAPULLO, Agostino;BIFULCO, Giuseppe;BRUNO, Ines;RICCIO, Raffaele
2000

Abstract

Chemical investigation of the Et2O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure bisindole alkaloids (1-13). Compounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human broncopulmonary cancer cells (NSCLC-N6) with an IC50 of 12 and 6.3 íg/mL, respectively
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/1065334
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 207
  • ???jsp.display-item.citation.isi??? 199
social impact