This letter describes the first example of diastereoselective ‘organocatalyzed’ synthesis of the butenolide products substituted at the c-position by a chain bearing hydroxyl groups. The urea-derivative 4 has proved to be an efficient catalyst for the addition of the commercial TMSOF to carbonyl compounds under solvent-free conditions. The reaction conditions and generality of the procedure have been examined.
The First Organocatalytic Addition of 2-Trimethylsilyloxyfuran to Carbonyl Compounds: Hydrogen-Bond Catalysis in g-Butenolides Synthesis
DE ROSA, Margherita;SORIENTE, Annunziata
2006-01-01
Abstract
This letter describes the first example of diastereoselective ‘organocatalyzed’ synthesis of the butenolide products substituted at the c-position by a chain bearing hydroxyl groups. The urea-derivative 4 has proved to be an efficient catalyst for the addition of the commercial TMSOF to carbonyl compounds under solvent-free conditions. The reaction conditions and generality of the procedure have been examined.File in questo prodotto:
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