SUMMARY In this last decade, structure and functions of the receptor for the urokinase-type plasminogen activator have been extensively studied and characterized. This interesting receptor plays a key role in cell adhesion, migration and proliferation. It was identified 20 years ago as the specific cell-surface molecule that could bind and concentrate urokinase on the cell membrane, thus initiating the proteolytic cascade promoted by the activation of plasminogen. The identification of new extracellular ligands, as vitronectin, and of cell-surface interactors, as integrins and fMLP receptors, shed a new light on its possible roles, totally independent of the enzymatic properties of its ligand. uPAR ligands and interactors and the functional consequences of the multiple binding capability of this intriguing receptor are here reviewed.

The urokinase receptor: a ligand or a receptor? Story of a sociable molecule.

RAGNO, Pia
2006-01-01

Abstract

SUMMARY In this last decade, structure and functions of the receptor for the urokinase-type plasminogen activator have been extensively studied and characterized. This interesting receptor plays a key role in cell adhesion, migration and proliferation. It was identified 20 years ago as the specific cell-surface molecule that could bind and concentrate urokinase on the cell membrane, thus initiating the proteolytic cascade promoted by the activation of plasminogen. The identification of new extracellular ligands, as vitronectin, and of cell-surface interactors, as integrins and fMLP receptors, shed a new light on its possible roles, totally independent of the enzymatic properties of its ligand. uPAR ligands and interactors and the functional consequences of the multiple binding capability of this intriguing receptor are here reviewed.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/1636266
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