Synthesis of new pyrido[4,3-g and 3,4-g]quinoline-5,10-dione and dihydrothieno[2,3-g and 3,2-g]quinoline-4,9-dione derivatives and preliminary evaluation of cytotoxic activity

Several pyrido[4,3-g and 3,4-g]quinoline-5,10-dione and dihydrothieno[2, 3-g and 3,2-g]quinoline-4,9-dione derivatives were synthesized and evaluated for their potential cytotoxic properties. A number of these compounds exhibited significant in vitro antiproliferative activity at submicromolar concentration in a preliminary evaluation for their cytotoxic activity using the MT-4 cell line. These structures represent potential scaffolds in discovery of new agents with antitumoral activity and the synthetic strategy developed could be used to prepare libraries of new derivatives by combinatorial chemistry.