Amides easily obtained from enantiopure (R)- and (S)-NOBIN and L-proline have been shown to promote the enantioselective direct aldol reaction under low catalytic loadings (5 mol%), in apolar hexane as the solvent and using only a slightly higher molar excess of the acetone with respect to the aldehyde. Aldol products are isolated in good to high yields and up to 77% ee at room temperature.

NOBIN-prolinamides organocatalyzed enantioselective direct aldol reaction: remarkable activity in apolar medium

RUSSO, ALESSIO;LATTANZI, Alessandra
2007

Abstract

Amides easily obtained from enantiopure (R)- and (S)-NOBIN and L-proline have been shown to promote the enantioselective direct aldol reaction under low catalytic loadings (5 mol%), in apolar hexane as the solvent and using only a slightly higher molar excess of the acetone with respect to the aldehyde. Aldol products are isolated in good to high yields and up to 77% ee at room temperature.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/1741859
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