Eight new oleanane saponins (1−8) together with four know saponins (9−12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.
Antiproliferative Oleanane Saponins from Meryta denhamii.
CIOFFI, Giuseppina;DAL PIAZ, FABRIZIO;DE CAPRARIIS, Paolo;DE TOMMASI, Nunziatina
2008
Abstract
Eight new oleanane saponins (1−8) together with four know saponins (9−12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.File in questo prodotto:
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