An inexpensive and regioselective approach to dihydrothieno[3,2-g]quinoline-4,9-dione is reported. A combination of a mild version of Skraup reaction with a sequential substitution/Michael addition allowed the selective preparation in acceptable yield of a pharmacologically important quinone derivative, previously obtained only in trace and together with the other regioisomer.
A regioselective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems
CASTELLANO, Sabrina;SANTORIELLO, MARISABELLA;CAMPIGLIA, Pietro;BERTAMINO, Alessia;SBARDELLA, Gianluca
2009-01-01
Abstract
An inexpensive and regioselective approach to dihydrothieno[3,2-g]quinoline-4,9-dione is reported. A combination of a mild version of Skraup reaction with a sequential substitution/Michael addition allowed the selective preparation in acceptable yield of a pharmacologically important quinone derivative, previously obtained only in trace and together with the other regioisomer.File in questo prodotto:
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