An inexpensive and regioselective approach to dihydrothieno[3,2-g]quinoline-4,9-dione is reported. A combination of a mild version of Skraup reaction with a sequential substitution/Michael addition allowed the selective preparation in acceptable yield of a pharmacologically important quinone derivative, previously obtained only in trace and together with the other regioisomer.

A regioselective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems

CASTELLANO, Sabrina;SANTORIELLO, MARISABELLA;CAMPIGLIA, Pietro;BERTAMINO, Alessia;SBARDELLA, Gianluca
2009-01-01

Abstract

An inexpensive and regioselective approach to dihydrothieno[3,2-g]quinoline-4,9-dione is reported. A combination of a mild version of Skraup reaction with a sequential substitution/Michael addition allowed the selective preparation in acceptable yield of a pharmacologically important quinone derivative, previously obtained only in trace and together with the other regioisomer.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/2289439
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