Acombination ofwater and microwave irradiationwas used for the first timeto performa catalyst-free nitro- Michael addition of pyrroles and indoles. Under superheated conditions, the water trends to ionize by changing its chemicalandphysical properties.Therefore,we performed a newgreen-protocol using thewater either as environmentally no harmsolvent or as catalyst. The reaction success is independent fromthe kind of pyrrole, indole or nitroalkenes rapidly affording the corresponding adducts and giving excellent yields.
A combination of water and microwave irradiation promotes the catalyst-free addition of pyrroles and indoles to nitroalkenes
DE ROSA, Margherita;SORIENTE, Annunziata
2010-01-01
Abstract
Acombination ofwater and microwave irradiationwas used for the first timeto performa catalyst-free nitro- Michael addition of pyrroles and indoles. Under superheated conditions, the water trends to ionize by changing its chemicalandphysical properties.Therefore,we performed a newgreen-protocol using thewater either as environmentally no harmsolvent or as catalyst. The reaction success is independent fromthe kind of pyrrole, indole or nitroalkenes rapidly affording the corresponding adducts and giving excellent yields.File in questo prodotto:
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