Manoalide, an analgesic and anti-inflammatory sesterterpene, has been stereoselectively synthesized for the first time. The C-4 stereogenic centre has been introduced in an early step by enantioselective aldol condensation using a Ti(OiPr)(4)/(R)-(+)-binol complex.
First enantioselective synthesis of manoalide: application of aldehyde–dioxinone enantioselective condensation
SORIENTE, Annunziata;DE ROSA, Margherita;SCETTRI, Arrigo;SODANO, Guido
1999-01-01
Abstract
Manoalide, an analgesic and anti-inflammatory sesterterpene, has been stereoselectively synthesized for the first time. The C-4 stereogenic centre has been introduced in an early step by enantioselective aldol condensation using a Ti(OiPr)(4)/(R)-(+)-binol complex.File in questo prodotto:
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