The first example of a convenient and enantioselective asymmetric conjugate addition of diarylphosphane oxides to chalcones is reported. By using commercially available dihydroquinine as the organocatalyst and diphenylphosphane oxide as the nucleophile, the adducts were isolated in high yield and up to 89% ee. The final adducts can be easily recrystallized to enantiopure material.
Asymmetric organocatalytic conjugate addition of diaryl phosphane oxides to chalcones
RUSSO, ALESSIO;LATTANZI, Alessandra
2010
Abstract
The first example of a convenient and enantioselective asymmetric conjugate addition of diarylphosphane oxides to chalcones is reported. By using commercially available dihydroquinine as the organocatalyst and diphenylphosphane oxide as the nucleophile, the adducts were isolated in high yield and up to 89% ee. The final adducts can be easily recrystallized to enantiopure material.File in questo prodotto:
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