Supercritical Assisted Atomization (SAA) has been successfully used for the production of polymer-drug microspheres for controlled release. Recently this technique has been proposed for the production of microspheres where bovine serum albumin (BSA) was used as carrier for several anti-inflammatory drugs. In this work the production of BSA/pectin (PC)/gentamicin sulfate (GS) microsphere is presented and the effect of drug/BSA/PC ratio on the release behaviour of GS is investigated. Size distribution and shape factor of the microspheres were determined by SEM image and laser scattering analysis. Drug release profiles were measured by Franz diffusion cell system using PBS buffer as acceptor solution. Microspheres produced by SAA showed a mean diameter between 1.5 μm and 2.0 μm, depending on the drug/polymers ratio used to produce the particles; particularly, the higher was the ratio the smaller was the mean diameter. All the microparticles exhibited very high loading capacity, with an encapsulation efficiency of about 100%. Drug release curves showed a prolonged release of GS depending on the drug/polymers ratio. Indeed, the higher was the quantity of BSA/PC mixture used to manufacture the microparticles the longer was the release of GS encapsulated.
Gentamicin loaded albumin/pectin microspheres for drug release obtained by SAA
ADAMI, RENATA;LIPAROTI, SARA;DELLA PORTA, Giovanna;DEL GAUDIO, Pasquale;AURIEMMA, GIULIA;PROTA, LUCIA;AQUINO, Rita Patrizia;REVERCHON, Ernesto
2010
Abstract
Supercritical Assisted Atomization (SAA) has been successfully used for the production of polymer-drug microspheres for controlled release. Recently this technique has been proposed for the production of microspheres where bovine serum albumin (BSA) was used as carrier for several anti-inflammatory drugs. In this work the production of BSA/pectin (PC)/gentamicin sulfate (GS) microsphere is presented and the effect of drug/BSA/PC ratio on the release behaviour of GS is investigated. Size distribution and shape factor of the microspheres were determined by SEM image and laser scattering analysis. Drug release profiles were measured by Franz diffusion cell system using PBS buffer as acceptor solution. Microspheres produced by SAA showed a mean diameter between 1.5 μm and 2.0 μm, depending on the drug/polymers ratio used to produce the particles; particularly, the higher was the ratio the smaller was the mean diameter. All the microparticles exhibited very high loading capacity, with an encapsulation efficiency of about 100%. Drug release curves showed a prolonged release of GS depending on the drug/polymers ratio. Indeed, the higher was the quantity of BSA/PC mixture used to manufacture the microparticles the longer was the release of GS encapsulated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
