Nine new phenolic compounds, 3S-hydrangenol 4'-O-alpha-L-rhamnopyranoysl-(1 -> 3)-beta-D-glucopyranoside (1), thunberginol F 7-O-beta-D-glucopyranoside (2), 2-hydroxy6-[2-(4-hydroxyphenyl)-2-oxo-ethyl]benzoic acid (3), 2-hydroxy-6-[2-(3,4-dihydroxyphenyl)-2-oxo-ethyl]benzoic acid (4), 2-hydroxy-6-[2-(3,4-dihydroxyphenyl-5-methoxy)-2-oxo-ethyl]benzoic acid (5), hydrangeic acid 4'-O-beta-D-glucopyranoside (6), E-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)dihydrofuran-2-one (7), Z-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-furanone (8), and 4-[beta-D-glucopyranosyl)hydroxy]-pinoresinol (9), and nine known compounds were isolated from the roots of Scorzonera judaica. Structures of 1-9 were elucidated by mass spectrometry, extensive 1D and 2D NMR spectroscopy, and CD spectroscopy. All compounds were evaluated for cytotoxic activity.
Phenolic Compounds from the Roots of Jordanian Viper's Grass, Scorzonera judaica.
DE TOMMASI, Nunziatina;COTUGNO, ROBERTA;
2011
Abstract
Nine new phenolic compounds, 3S-hydrangenol 4'-O-alpha-L-rhamnopyranoysl-(1 -> 3)-beta-D-glucopyranoside (1), thunberginol F 7-O-beta-D-glucopyranoside (2), 2-hydroxy6-[2-(4-hydroxyphenyl)-2-oxo-ethyl]benzoic acid (3), 2-hydroxy-6-[2-(3,4-dihydroxyphenyl)-2-oxo-ethyl]benzoic acid (4), 2-hydroxy-6-[2-(3,4-dihydroxyphenyl-5-methoxy)-2-oxo-ethyl]benzoic acid (5), hydrangeic acid 4'-O-beta-D-glucopyranoside (6), E-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)dihydrofuran-2-one (7), Z-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-furanone (8), and 4-[beta-D-glucopyranosyl)hydroxy]-pinoresinol (9), and nine known compounds were isolated from the roots of Scorzonera judaica. Structures of 1-9 were elucidated by mass spectrometry, extensive 1D and 2D NMR spectroscopy, and CD spectroscopy. All compounds were evaluated for cytotoxic activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
