2-Dibenzylamino-5-oxopentanoic acid benzyl ester has been obtained in good yields by complete benzylation of L-glutamic acid in NaOH and Na2CO3, selective redn. of the γ-ester into alc. with DIBAL and further transformation into aldehyde using Swern oxidn. The overall three-step procedure from Glu gave aldehyde in good yield.
A simple procedure for the transformation of L-glutamic acid into the corresponding γ-aldehyde
RODRIQUEZ, Manuela;
2005
Abstract
2-Dibenzylamino-5-oxopentanoic acid benzyl ester has been obtained in good yields by complete benzylation of L-glutamic acid in NaOH and Na2CO3, selective redn. of the γ-ester into alc. with DIBAL and further transformation into aldehyde using Swern oxidn. The overall three-step procedure from Glu gave aldehyde in good yield.File in questo prodotto:
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