1,3-Alternate calix[4]arenes, decorated with four nonpolar ‘all-trans’ tetracyclic nuclei and cation-stabilizing beta-methoxyethoxy appendages, were synthesized from commercially available starting materials and through straightforward functional groups transformations/ couplings. Their Na+-transport activities, when compared with those exerted by the known conformationally-rigidified 1,3-alternate calix[4]-arene AB/cis cholic acid conjugates, suggest that the cation conductance is related to the morphology of the pendant steroids.

On the Importance of the Pore Inner Cavity for the Ionophoric Activity of 1,3-Alternate Calix[4]arene/Steroid Conjugates

IZZO, Irene;CASAPULLO, Agostino;DE RICCARDIS, Francesco
2006-01-01

Abstract

1,3-Alternate calix[4]arenes, decorated with four nonpolar ‘all-trans’ tetracyclic nuclei and cation-stabilizing beta-methoxyethoxy appendages, were synthesized from commercially available starting materials and through straightforward functional groups transformations/ couplings. Their Na+-transport activities, when compared with those exerted by the known conformationally-rigidified 1,3-alternate calix[4]-arene AB/cis cholic acid conjugates, suggest that the cation conductance is related to the morphology of the pendant steroids.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/3093957
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