Automatic synthesis of4-[18F]fluorobenzaldehyde has been developed by a commercially available TRACERlabTM FXF_N synthesis module to be used as prosthetic group for amino-oxyfunctionalized peptide labellinginclinicalroutineapplication.Inadditionahandmadepurificationdevice(HPD)has been setuptoperformautomaticcartridgepurificationaswellastoback-upthereactorwhereone-pot synthesisisnotapplicable.CartridgesforsolidphaseextractionsuchasC18,C8,phenylhasbeentested to bestperformpurificationaswellasactivityrecovery.Radiochemicalyield(RCY)atendofsynthesis (EOS) wasinaverage67%afterabout45min(90%decaycorrectedatEOB).TheRCYoftheentire procedure was54%witharadiochemicalpurityabove99%.
Fully automated synthesis procedure of 4-[18F]fluorobenzaldehyde by commercial synthesizer: amino-oxi peptide labelling prosthetic group
PACE, Leonardo;
2009-01-01
Abstract
Automatic synthesis of4-[18F]fluorobenzaldehyde has been developed by a commercially available TRACERlabTM FXF_N synthesis module to be used as prosthetic group for amino-oxyfunctionalized peptide labellinginclinicalroutineapplication.Inadditionahandmadepurificationdevice(HPD)has been setuptoperformautomaticcartridgepurificationaswellastoback-upthereactorwhereone-pot synthesisisnotapplicable.CartridgesforsolidphaseextractionsuchasC18,C8,phenylhasbeentested to bestperformpurificationaswellasactivityrecovery.Radiochemicalyield(RCY)atendofsynthesis (EOS) wasinaverage67%afterabout45min(90%decaycorrectedatEOB).TheRCYoftheentire procedure was54%witharadiochemicalpurityabove99%.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.