Celiac disease (CD) is a gluten-sensitive enteropathy with an immune basis. We established the immune reactivity of the alcohol-soluble fraction from two minor cereals (tef and millet) and two pseuocereals (amaranth and quinoa) which are believed to be nontoxic based on taxonomy. Grains were examined in intestinal T-cell line (iTCLs), cultures of duodenal explants from HLA-DQ2+ CD patients and HLA-DQ8 transgenic mice for signs of activation. Our data indicated that tef, millet, amaranth, and quinoa did not show any immune cross-reactivity toward wheat gliadin and therefore confirming their safety in th diet of CD patients.
Immunological evaluation of the alcohol-soluble protein fraction from gluten-free grains in relation to celiac disease
DE FALCO, Enrica;
2011-01-01
Abstract
Celiac disease (CD) is a gluten-sensitive enteropathy with an immune basis. We established the immune reactivity of the alcohol-soluble fraction from two minor cereals (tef and millet) and two pseuocereals (amaranth and quinoa) which are believed to be nontoxic based on taxonomy. Grains were examined in intestinal T-cell line (iTCLs), cultures of duodenal explants from HLA-DQ2+ CD patients and HLA-DQ8 transgenic mice for signs of activation. Our data indicated that tef, millet, amaranth, and quinoa did not show any immune cross-reactivity toward wheat gliadin and therefore confirming their safety in th diet of CD patients.File in questo prodotto:
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