The results of resting planar ECG-gated technetium- 99m methoxyisobutylisonitrile (99mTc-MIBI) imaging were compared with those of thallium-201 (T1) reinjection after exercise-redistribution scintigraphy in 20 patients (19 men, 1 woman, mean age 53_10 years) with angiographically proven coronary artery disease. Eight normal subjects (seven men, one woman, mean age 50___8 years) constituted the control group. In these subjects, only resting 99mTc-MIBI imaging was performed. The standardized percent count increase from end-diastole to end-systole was calculated as an index of wall thickening in 13 segments for each study. Regional wall thickening index (WTI) and 99mTc-MIBI uptake were significantly different (P<0.05) among segments classified as normal, reversible defects, irreversible defects with increased tracer uptake after re-injection (Re+) or irreversible defects with unchanged tracer uptake after re-injection (Re-) on T1 imaging. Furthermore, WTI and 99mTCMIBI uptake were significantly higher (P<0.05) in Resegments with moderate reduction of T1 uptake (>_50% of peak activity) than in Re- segments with severe reduction of T1 uptake (<50% of peak activity). A significant relationship between WTI and the results of T1 scintigraphy was observed (rho=0.71, P<0.0001). The percentage of Re- segments with severe reduction of WTI was significantly higher compared to Re+ segments (64% vs 3%, P<0.01). Furthermore, compared with moderate Re- segments, a significantly higher percentage of severe Re- segments showed a severe reduction of WTI (86% vs 48%, P<0.01). Our data document a close relationship between 99mTc-MIBI regional wall thickening, myocardial perfusion and T1 uptake after reinjection. The results of this study suggest that regional Correspondence to: A. Cuocolo, Via Posillipo 66, 1-80123 Napoli, Italy WTI decreased significantly as myocardial perfusion decreased. In addition, regional wall thickening was preserved in segments with exercise-induced ischaemia and enhanced T1 uptake after re-injection.
Assessment of Systolic Wall Thickening Using Technetium-99m Methoxyisobutylisonitrile in Patients with Coronary Artery Disease: Relation to Thallium-201 Scintigraphy with Reinjection
PACE, Leonardo;
1995-01-01
Abstract
The results of resting planar ECG-gated technetium- 99m methoxyisobutylisonitrile (99mTc-MIBI) imaging were compared with those of thallium-201 (T1) reinjection after exercise-redistribution scintigraphy in 20 patients (19 men, 1 woman, mean age 53_10 years) with angiographically proven coronary artery disease. Eight normal subjects (seven men, one woman, mean age 50___8 years) constituted the control group. In these subjects, only resting 99mTc-MIBI imaging was performed. The standardized percent count increase from end-diastole to end-systole was calculated as an index of wall thickening in 13 segments for each study. Regional wall thickening index (WTI) and 99mTc-MIBI uptake were significantly different (P<0.05) among segments classified as normal, reversible defects, irreversible defects with increased tracer uptake after re-injection (Re+) or irreversible defects with unchanged tracer uptake after re-injection (Re-) on T1 imaging. Furthermore, WTI and 99mTCMIBI uptake were significantly higher (P<0.05) in Resegments with moderate reduction of T1 uptake (>_50% of peak activity) than in Re- segments with severe reduction of T1 uptake (<50% of peak activity). A significant relationship between WTI and the results of T1 scintigraphy was observed (rho=0.71, P<0.0001). The percentage of Re- segments with severe reduction of WTI was significantly higher compared to Re+ segments (64% vs 3%, P<0.01). Furthermore, compared with moderate Re- segments, a significantly higher percentage of severe Re- segments showed a severe reduction of WTI (86% vs 48%, P<0.01). Our data document a close relationship between 99mTc-MIBI regional wall thickening, myocardial perfusion and T1 uptake after reinjection. The results of this study suggest that regional Correspondence to: A. Cuocolo, Via Posillipo 66, 1-80123 Napoli, Italy WTI decreased significantly as myocardial perfusion decreased. In addition, regional wall thickening was preserved in segments with exercise-induced ischaemia and enhanced T1 uptake after re-injection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
