To compare rest-injected thallium-201 (T1) redistribution and resting technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) myocardial uptake in chronic coronary artery disease (CAD), 15 patients with angiographically proven CAD and left ventricular (LV) dysfunction (ejection fraction 34% +9%) were studied. All patients underwent rest-redistribution T1 and resting 99mTc-MIBI cardiac imaging. Gated 99mTc-MIBI images were also acquired to assess regional LV wall motion (WM). Myocardial segments (n = 225) were divided into three groups on the basis of the degree of coronary artery stenosis: group 1 (total occlusion, n-- 82), group 2 (50%- 99% of stenosis, n= 84) and group 3 (< 50% of stenosis, n = 59). WM was significantly worse in groups 1 and 2 compared to group 3 (P<0.001), but no difference was observed between groups 1 and 2. T1 and 99mTc-MIBI uptake were significantly lower in groups 1 and 2 compared to group 3 (P < 0.001), and in group 1 compared to group 2 (P<0.001). When T1 and 99mTc-MIBI uptake were directly compared, T1 uptake was higher than 99mTc-MIBI uptake in group 1 (P <0.001), while no significant difference was observed in groups 2 and 3. Thus, both rest-injected T1 redistribution and resting 99mTCMIBI uptake reflected the severity of coronary artery stenosis in CAD. However, in myocardial segments with total coronary occlusion T1 uptake was significantly higher than 99mTc-MIBI uptake. Our data suggest that rest-injected T1 redistribution cardiac imaging may identify, more accurately than resting 99mTc-MIBI imaging, the presence of viable myoeardium in chronic CAD, particularly when the coronary blood flow is severely impaired.

Rest-Injected Thallium-201 Redistribution and Technetium-99m Methoxyisobutylisonitrile Uptake in Coronary Artery Disease: Relation to the Severity of Coronary Artery Disease

PACE, Leonardo;
1993

Abstract

To compare rest-injected thallium-201 (T1) redistribution and resting technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) myocardial uptake in chronic coronary artery disease (CAD), 15 patients with angiographically proven CAD and left ventricular (LV) dysfunction (ejection fraction 34% +9%) were studied. All patients underwent rest-redistribution T1 and resting 99mTc-MIBI cardiac imaging. Gated 99mTc-MIBI images were also acquired to assess regional LV wall motion (WM). Myocardial segments (n = 225) were divided into three groups on the basis of the degree of coronary artery stenosis: group 1 (total occlusion, n-- 82), group 2 (50%- 99% of stenosis, n= 84) and group 3 (< 50% of stenosis, n = 59). WM was significantly worse in groups 1 and 2 compared to group 3 (P<0.001), but no difference was observed between groups 1 and 2. T1 and 99mTc-MIBI uptake were significantly lower in groups 1 and 2 compared to group 3 (P < 0.001), and in group 1 compared to group 2 (P<0.001). When T1 and 99mTc-MIBI uptake were directly compared, T1 uptake was higher than 99mTc-MIBI uptake in group 1 (P <0.001), while no significant difference was observed in groups 2 and 3. Thus, both rest-injected T1 redistribution and resting 99mTCMIBI uptake reflected the severity of coronary artery stenosis in CAD. However, in myocardial segments with total coronary occlusion T1 uptake was significantly higher than 99mTc-MIBI uptake. Our data suggest that rest-injected T1 redistribution cardiac imaging may identify, more accurately than resting 99mTc-MIBI imaging, the presence of viable myoeardium in chronic CAD, particularly when the coronary blood flow is severely impaired.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/3104809
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