The bone surrounding a prosthetic implant normally experiences a progressive quantitative reduction as a result of stress shield- ing and wear debris production, that can lead to the aseptic loos- ening of the implant. Dual-energy X-ray absorptiometry (DXA), using software algorithms, can ensure a surrogate measure of load redistribution after the implant of the prosthetic compo- nents and can be a valid tool to evaluate the efficacy of pharma- cological therapy to reduce the periprosthetic bone loss. In sev- eral animal and human studies DXA has been able to quantify antiresorptive action of bisphosphonates in the periprosthetic area.

Periprosthetic bone density as outcome of therapeutic response

GATTO, Salvatore;
2010

Abstract

The bone surrounding a prosthetic implant normally experiences a progressive quantitative reduction as a result of stress shield- ing and wear debris production, that can lead to the aseptic loos- ening of the implant. Dual-energy X-ray absorptiometry (DXA), using software algorithms, can ensure a surrogate measure of load redistribution after the implant of the prosthetic compo- nents and can be a valid tool to evaluate the efficacy of pharma- cological therapy to reduce the periprosthetic bone loss. In sev- eral animal and human studies DXA has been able to quantify antiresorptive action of bisphosphonates in the periprosthetic area.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/3125082
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