Bioactive Prenylhydroquinone Sulfates and a Novel C31 Furanoterpene Alcohol Sulfate from the Marine Sponge, Ircinia Sp.

Prenylhydroquinone sulfates have been isolated from a marine sponge, Ircinia sp., collected off New Caledonia. These compds. bind to the neuropeptide Y receptor, inhibit the tyrosine protein kinase and HIV-integrase enzymes, and co-occur with a mixt. of sulfated prenylated chromanols and chromenols, prenylhydroquinones, and the corresponding quinones and chromenols. A hydroxylated heptaprenylhydroquinone, which proved to be active against tyrosine protein kinase, was also isolated, as well as a novel C31 furanoterpene alc. sulfate, named ircinol sulfate.