Two novel sulfated polyhydroxysteroids, I, possessing potent cytotoxic activity, and II, which proved to be cytoprotective against HIV-1, were isolated from the Antarctic ophiuroid Ophiosparte gigas, together with the known compd. III. The structures of I and II were detd. to be cholest-5-ene-2α,3α,4β, 21-tetraol 3,21-disulfate and cholest-5-ene-2β,3α, 21-triol 2,21-disulfate, resp.

Isolation and Structure Characterization of Two Novel Bioactive Sulphated Polyhydroxysteroids from the Antarctic OphiuroidOphioderma longicaudum

RICCIO, Raffaele;
1993-01-01

Abstract

Two novel sulfated polyhydroxysteroids, I, possessing potent cytotoxic activity, and II, which proved to be cytoprotective against HIV-1, were isolated from the Antarctic ophiuroid Ophiosparte gigas, together with the known compd. III. The structures of I and II were detd. to be cholest-5-ene-2α,3α,4β, 21-tetraol 3,21-disulfate and cholest-5-ene-2β,3α, 21-triol 2,21-disulfate, resp.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11386/3128281
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