A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values of 3-13 μM against HIV-1 (RF) and 2-8 μM against HIV-2 (CBL20). Those compds. which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.
HIV-Inhibitory Natural Products. 11. Comparative Studies of Sulfated Sterols from Marine Invertebrates
RICCIO, Raffaele;
1994-01-01
Abstract
A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values of 3-13 μM against HIV-1 (RF) and 2-8 μM against HIV-2 (CBL20). Those compds. which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.File in questo prodotto:
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