Epimeric (24S)- and (24R)-24-hydroxymethyl steroids I were synthesized as model compds. of established abs. configuration for stereochem. assignments in side chains of polyhydroxylated marine steroids e.g., coscinasteroside C. Anal. of the NMR spectral data of synthetic compds. and of their α-methoxy-α(trifluoromethyl)phenylacetyl derivs. proved the suitability of NMR spectroscopy for the assignment of configuration at C-24 in 24-hydroxymethyl steroids.

STEREOSELECTIVE SYNTHESIS OF (24S) AND (24R)-24-(HYDROXYMETHYL)CHOLESTA-5,22(E)-DIEN-3-BETA-OL - MODEL COMPOUNDS FOR STEREOCHEMICAL ASSIGNMENTS OF POLYHYDROXYLATED MARINE STEROIDS

RICCIO, Raffaele;
1990

Abstract

Epimeric (24S)- and (24R)-24-hydroxymethyl steroids I were synthesized as model compds. of established abs. configuration for stereochem. assignments in side chains of polyhydroxylated marine steroids e.g., coscinasteroside C. Anal. of the NMR spectral data of synthetic compds. and of their α-methoxy-α(trifluoromethyl)phenylacetyl derivs. proved the suitability of NMR spectroscopy for the assignment of configuration at C-24 in 24-hydroxymethyl steroids.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11386/3128689
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