Arenecarboxaldehydes reacted with 2-(hydroxyiminomethyl)-1,4-dimethylpyridinium iodide (I) [57093-29-5] giving 12 title derivs. and with the 4-(hydroxyiminomethyl) analog (II) giving 4 title derivs. all of which were highly effective acetylcholinesterase [9000-81-1] inhibitors. I, II, and trans-4-imidazolylethenylpyridine-2-aldoxime methiodide (III) [57093-41-1] were the only substances which were active as reactivators of phosphorylated elec. eel cholinesterase in vitro. Structure-activity relations were discussed.
Structure-activity relations in reactivators of organophosphorus-inhibited acetylcholinesterase. 10. Hydroxyiminomethylarylethenylpyridine methiodides
PIZZA, Cosimo;
1975-01-01
Abstract
Arenecarboxaldehydes reacted with 2-(hydroxyiminomethyl)-1,4-dimethylpyridinium iodide (I) [57093-29-5] giving 12 title derivs. and with the 4-(hydroxyiminomethyl) analog (II) giving 4 title derivs. all of which were highly effective acetylcholinesterase [9000-81-1] inhibitors. I, II, and trans-4-imidazolylethenylpyridine-2-aldoxime methiodide (III) [57093-41-1] were the only substances which were active as reactivators of phosphorylated elec. eel cholinesterase in vitro. Structure-activity relations were discussed.File in questo prodotto:
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