Benzothiazines I [R1 = H, R2 = Me, Ph; R1 = Me, R2 = Ph; R1R2 = (CH2)4] and thiazines II [R1 = H, R2 = Me; R1R2 = (CH2)4] were prepd. in 23-59% yield by treatment of III or IV with p-MeC6H4SO3H in MePh at reflux for 30 min. III were prepd. in 13-81% yield by oxidn. of the resp. sulfide; unsym. 2-substituted dihydrobenzothiazoles gave a mixt. of 2 diastereoisomeric sulfoxides.
A New Synthesis of 4H-1,4-Thiazines and Benzothiazines
OLIVA, Leone;
1978-01-01
Abstract
Benzothiazines I [R1 = H, R2 = Me, Ph; R1 = Me, R2 = Ph; R1R2 = (CH2)4] and thiazines II [R1 = H, R2 = Me; R1R2 = (CH2)4] were prepd. in 23-59% yield by treatment of III or IV with p-MeC6H4SO3H in MePh at reflux for 30 min. III were prepd. in 13-81% yield by oxidn. of the resp. sulfide; unsym. 2-substituted dihydrobenzothiazoles gave a mixt. of 2 diastereoisomeric sulfoxides.File in questo prodotto:
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